O060 The relationship between sleep and appetitive conditioning: A systematic review and meta-analysis

Abstract Appetitive conditioning involves learning to associate previously neutral stimuli with pleasant or rewarding cues. Elements of appetitive underpin various maladaptive consummatory behaviours, including regular consumption unhealthy foods, recreational substance use, and clinical symptoms certain mental disorders (e.g., binge-eating disorder, use disorder). One modifiable mechanism underlying appears be sleep, due its critical role in new learning. This systematic review meta-analysis (PROSPERO registration: CRD42021234793) examined the relationship between sleep conditioning. Inclusion criteria included: a) paradigm; b) measure conditioning; c) measurement and/or loss; d) written English. Searches seven databases returned 3343 publications as March 2022. The final sample consisted 40 studies using animal models. No human were identified. We found: loss interfered tasks involving natural reinforcers (i.e., food; p < 0.001); drug showed potentiating effects (p extinction was negatively impacted by loss, irrespective reinforcer; post-learning associated increases REM = 0.02). Findings suggest potentiates impact psychoactive substances produce an increased risk problematic use. indicates may important target treating disorders. In obese/overweight populations deficits reward behaviours. Further research is needed assess humans.